国内特許出願番号：特願平11-3444795，国際出願番号PCT/JP00/008529, 発明の名称：新規な小胞体局在タンパク質およびそれを含む糖タンパク質異常症治療薬，並びに 該タンパク質をコードするDNAおよびそれを含む糖タンパク質異常症治療のための遺伝子治療薬， 出願人：甲斐広文 (2000)

Takahashi K, Iwase N, Ishikawa M, Mizuno H, Koda T, Kai H, Miyata T. 　[Effects of fudosteine, a new cysteine derivative, on airway secretion in rabbits and rats]　Nippon Yakurigaku Zasshi. 2000;116(6):371-8.

Suzuki K, Shono F, Kai H, Uno T, Uyeda M. 　Inhibition of topoisomerases by fatty acids.　J Enzyme Inhib. 2000;15(4):357-66.

Okumura M, Kai H, Arimori K, Iwakiri T, Hidaka M, Shiramoto S, Isohama Y, Miyata T. 　Adrenomedullin increases phosphatidylcholine secretion in rat type II pneumocytes.　Eur J Pharmacol. 2000;403(3):189-94.

Y. Ikeda, K. Kimura, F. Hirayama, H. Arima and K. Uekama, Controlled release of a water-soluble drug, captopril, by a combination of hydrophilic and hydrophobic cyclodextrin derivatives. J. Control. Release, 66 , 271-280, 2000.

K. Kimura, F. Hirayama, H. Arima and K. Uekama, Selective crystallization of tolbuamide polymorphs controlled by inclusion complexation with amorphous 2-hydroxypropyl-a- and b-cyclodextrins. Chem. Pharm. Bull., 48 , 646-650, 2000.

Y. Aramaki, S. Takano, H. Arima and S. Tsuchiya. Induction of apoptosis in WEHI 231 cells by cationic liposomes. Pharm. Res., 17 , 515-520, 2000.

K. Miyake, H. Arima, F. Hirayama, M. Yamamoto, T. Horikawa, H. Sumiyoshi, S. Noda and K. Uekama, Improvement of solubility and oral bioavailability of rutin by complexation with 2-hydroxypropyl-b-cyclodextrin. Pharm. Develop. Tech., 5 , 399-407, 2000.

K. Tokihiro, H. Arima, S. Tajiri, T. Irie, F. Hirayama and K. Uekama, Improvement of subcutaneous bioavailability of insulin by sulfobutyl ether b-cyclodextrin in rats. J. Pharm. Pharmacol., 52 , 911-917, 2000.

F. Hirayama, M. Honjo, H. Arima, K. Okimoto and K. Uekama, Characterizatin of nilvadipine monohydrate: crystal structure and phase transition behavior. Eur. J. Pharm. Sci., 11 , 81-88, 2000.

H. Yano, F. Hirayama, H. Arima and K. Uekama, Hydrolysis behavior of predonisolone 21-hemisuccinate/b-cyclodextrin amide conjugate: Involvement of intramolecular catalysis of amide group in drug release. Chem. Pharm. Bull., 48 , 1125-1128, 2000.

F. Hirayama, T. Ogata, H. Yano, H. Arima, K. Udo, M. Takano and K. Uekama, Release characteristics of a short-chain fatty acid, n -butyric acid, from its b-cyclodextrin ester conjugate in rat biological media. J. Pharm. Sci., 89 , 1486-1495, 2000.