熊本大学大学院生命科学研究部 遺伝子機能応用学分野

A.Imasato , C. Desbois-Mouthon, J.Han, H.Kai, A.C.B.Cato, S.Akira, J.-D.Li, Inhibition of p38 MAPK by Glucocorticoids via induction of MAPK phosphatase-1 enhances nontypeable Haemophilus influenzae-induced expression of Toll-like receptor 2. J.Biol.Chem. 277. 47444-47450 (2002)

H. Jono, T. Shuto, H. Xu, H. Kai, D. J Lim, J. R Gum, Y. S Kim, S. Yamaoka, X.-H. Feng, and J.-D. Li
TGF-b-Smad signaling pathway cooperates with NF-kB to mediate nontypeable Haemophilus influenzae-induced MUC2 mucin transcription J. Biol. Chem., 277, 45547-45557 (2002)

Y. Seki, M.-A. Suico, A. Uto, A. Hisatsune, T. Shuto, Y. Isohama, and H. Kai, The ETS transcription factor MEF is a candidate tumor suppressor gene on the X chromosome, Cancer Res 62: 6579-6586 (2002)

S. Kunimoto, W. Murofushi, H. Kai, Y. Ishida, A. Uchiyama, T. Kobayashi, S. Kobayashi, H. Murofushi, K. Murofushi-Murakami, Steryl Glucoside is a lipid mediator in stress-responsive signal transduction. Cell Structure Function,27, 157-162 (2002)

T. Okiyoneda, I. Wada, H. Jono, T. Shuto, K. Yoshitake, N. Nakano, S. Nagayama, K. Harada, Y. Isohama, T. Miyata, H. Kai
Calnexin Δ185-520 partially reverses the misprocessing of the ΔF508 cystic fibrosis transmembrane conductance regulator. FEBS letters, 526, 87-92 (2002)

Y. Ando, M. Nakamura, H. Kai, S. Katsuragi, H. Terazaki, T. Nozawa, T. Okuda, S. Misumi, N. Matsunaga, K. Hata, T. Tajiri, S. Shoji, T. Yamashita, K. Haraoka, K. Obayashi, K. Matsumoto, M. Ando, and M. Uchino, A novel localized amyloidosis associated with lactoferrin in the cornea. Lab. Invest. 82, 757-766, 2002

特願 2002-137944,発明の名称;アミロイドーシスの予防及び治療のための医薬,発明者:甲斐広文,安東由喜雄(2002)

Tajiri T, Ando Y, Hata K, Kamiide K, Hashimoto M, Nakamura M,Terazaki H, Yamashita T, Kai H, Haraoka K, Imasato A, Takechi K, Nakagawa K, Ishizaki T. Amyloid formation in rat transthyretin: effect of oxidative stress. Clin Chim Acta. 323(1-2):129-37 (2002).

M.-A. Suico, T. Koyanagi, S. Ise, Z. Lu, A. Hisatsune, Y. Seki, T. Shuto, Y. Isohama, T. Miyata, and H. Kai, Functional dissection of the ETS transcription factor MEF, Biochem. Biochim. Acta, 1577, 113-120 (2002).

Okiyoneda T, Kai H. Introduction of the conventional method of DNA transfection by adenovirus vector. Nippon Yakurigaku Zasshi.119(6):337-44. (Japanese)(2002).

Shuto T, Imasato A, Jono H, Sakai A, Xu H, Watanabe T, Rixter DR, Kai H, Andalibi A, Linthicum F, Guan YL, Han J, Cato AC, Lim DJ, Akira S, Li JD. Glucocorticoids synergistically enhance nontypeable Haemophilus influenzae-induced Toll-like receptor 2 expression via a negative cross-talk with p38 MAP kinase. J Biol Chem. 2002 May 10;277(19):17263-17270.

甲斐広文,首藤 剛.分子シャペロンをターゲットにした創薬研究.ファルマシア,2002,Vol.38, 296-300.

H. Yano, F. Hirayama, M. Kamada, H. Arima, K. Uekama, Colon-specific delivery of prednisolone-appended a-cyclodextrin conjugate: alleviation of systemic side effect after oral administration. J. Control Release. 79, 103-112, 2002.

Y. Nagase, M. Hirata, H. Arima, S. Tajiri, Y. Nishimoto, F. Hirayama, T. Irie, K. Uekama, Novel protective effect of sulfobutyl ether b-cyclodextrin on DY-9760e-induced hemolysis to in vitro. J. Pharm. Sci., in press, 2002.

H. Arima, F. Hirayama, C.T. Okamoto and K. Uekama, Recent aspects of cyclodextrin-based pharmaceutical formulations. メRecent Research Developments in Chemical & Pharmaceutical Sciences", Transworld Research Network, India, 2002, in press.