熊本大学大学院生命科学研究部 遺伝子機能応用学分野

Yoshida H, Jono H, Kai H, Li JD. The tumor suppressor CYLD acts as a negative regulator for toll-like receptor 2 signaling via negative cross-talk with TRAF6 and TRAF7. J Biol Chem., 2005 Dec 9;280(49):41111-21. Epub 2005 Oct 17.

Shuto, T., Kato, K., Mori, Y., Viriyakosol, S., Oba, M., Furuta, T., Okiyoneda,
T., Arima, H., Suico, M. A., and Kai, H. Membrane-anchored CD14 is required for
LPS-induced TLR4 endocytosis in TLR4/MD-2/CD14 overexpressing CHO cells.
Biochemical & Biophysical Research Communications, 2005 Dec 23;338(3):1402-9. Epub 2005 Oct 26.

T Koga, H Harada, SS Tea, S Okada, MA Suico, T Shuto and H Kai, Hyperthermia suppresses the cytotoxicity of NK cells via down-regulation of perforin/granzyme B expression., Biochem Biophys Res Commun. 2005 Dec 2;337(4):1319-23.

Mikami F, Gu H, Jono H, Andalibi A, Kai H, Li JD. Epidermal growth factor receptor acts as a negative regulator for bacterium nontypeable Haemophilus influenzae-induced toll-like receptor 2 expression via a Src-dependent p38 MAP kinase signaling pathway. J Biol Chem. 2005 Oct 28;280(43):36185-94.

Shuji Shimohara, Toru Murakami, Mari Morikawa, Junko Matsuo, Shin- ichi Nagayama, Tsuyoshi Shuto, Mary Ann Suico, Tsukasa Okiyoneda,
Isao Yamatsu, Toru Mizushima, Tatsuya Shimasaki and Hirofumi Kai,
Vitamins K1 and K2 potentiate hyperthermia by down regulating Hsp72
expression in vitro and in vivo. International Journal of Oncology. Int J Oncol. 2005 Dec;27(6):1527-33.

原田一恒, 沖米田司, 首藤 剛, 甲斐広文. 小胞体分子シャペロンカルレティキュリンによるCFTR細胞内輸送制御機構のsiRNAを用いた解析,炎症と免疫, vol.13 no.1, 19-25 (2005)

T. Roger, I. Miconnet, A.-L. Schiesser, H. Kai, K. Miyake, T. Calandra. Critical role for Ets, AP-1 and GATA-like transcription factors in regulating mouse Toll-like receptor 4 (Tlr4) gene expression, Biochem. J. 387, 355-365 (2005)

T. Koga, M.A. Suico, H. Nakmura, M. Taura, Z. Lu, T. Shuto, T. Okiyoneda, H. Kai. Sp1-dependent regulation of Myeloid Elf-1 like factor in human epithelial cells. FEBS letter. 579 (13), 2811-2816 (2005)