熊本大学大学院生命科学研究部 遺伝子機能応用学分野

Mikami F, Lim JH, Ishinaga H, Ha UH, Gu H, Koga T, Jono H, Kai H, Li JD. TGF-beta -Smad3/4 signaling pathway acts as a positive regulator for TLR2 induction by bacteria via a dual-mechanism involving functional cooperation with NF-kbeta and MAPK phosphatase 1-dependent negative cross-talk with p38 MAPK.  J Biol Chem. 281, 22397-22408, 2006.(2006)

Tsukasa Okiyoneda, Taijun Kono, Akiko Niibori, Kazutsune Harada, Hiroyuki Kusuhara, Tappei Takada, Tsuyoshi Shuto, Mary Ann Suico, Yuichi Sugiyama, Hirofumi Kai, Calreticulin Facilitates the Cell Surface Expression of ABCG5/G8, Biochem. Biophys. Res. Commun. 347, 67-75(2006)

Kazutsune Harada ,Tsukasa Okiyoneda,Yasuaki Hashimoto,Keiko Ueno,
Kimitoshi Nakamura,Kaori Yamahira Takuya Sugahara,Tsuyoshi Shuto,
Ikuo Wada,Mary Ann Suico and Hirofumi Kai.
Calreticulin negatively regulates the cell surface expression of CFTR.
J Biol Chem. 281: 12841-12848(2006)

Hidaka M, Okumura M, Ogikubo T, Kai H, Fujita KI, Iwakiri T, Yamasaki K, Setoguchi N, Matsunaga N, Arimori K. Transient inhibition of CYP3A in rats by star fruit juice. Drug Metab Dispos.;34(3):343-5 (2006)

Shuto, T., Furuta, T., Oba, M., Xu, H., Li, JD., Cheung, J., Gruenert, DC., Uehara, A., Suico, MA., Okiyoneda, T., and Kai, H. Promoter hypomethylation of toll-like receptor-2 gene is associated with increased proinflammatory response towards bacterial peptidoglycan in cystic fibrosis bronchial epithelial cells. FASEB J.. 20: 782-784, (2006)

Sato, T., Ando, Y., Susuki, S., Mikami, F., Ikemizu, S., Nakamura, M., Suhr, O., Anraku, M., Kai, T., Suico, MA., Shuto, T., Mizuguchi, M., Yamagata, Y., and Kai, H. Chromium (III) ion and thyroxine cooperate to stabilize the transthyretin tetramer and suppress in vitro amyloid fibril formation. FEBS letter., ;580(2):491-6.(2006)

Suico M.A., Nakamura H., Lu Z., Saito H., Shuto T., Nakao M. and Kai H. SUMO down-regulates the activity of Elf4/Myeloid Elf-1-like factor. Biochem. Biophys. Res. Commun. 348: 880-888,(2006)

Okiyoneda T., Niibori A., Harada K., Kono T., Kusuhara H., Takada T., Shuto T., Suico M.A., Sugiyama Y. and Kai H.Bafilomycin A1-Sensitive Pathway is required for the Maturation of Cystic Fibrosis Transmembrane Conductance Regulator. Biochem. Biochim. Acta(Mol. Cell Res.)in press,(2006)

橋本 泰明,沖米田 司,甲斐 広文
「RIの逆襲」チャネル研究におけるアイソトープの活用
~125Iを用いたクロライドチャネルCFTRのチャネル活性評価法~
細胞工学 「RIの逆襲」vol.25 No.9 2006 1082-1088