熊本大学大学院生命科学研究部 遺伝子機能応用学分野

Kariya R, Taura M, Suzu S, Kai H, Katano H, Okada S.
HIV protease inhibitor Lopinavir induces apoptosis of primary effusion lymphoma cells via suppression of NF-κB pathway.
Cancer Lett. 2014 Jan 1;342(1):52-9. doi: 10.1016/j.canlet.2013.08.045.

Kondo T, Ono K, Kitano S, Matsuyama R, Goto R, Suico MA, Kawasaki S, Igata M, Kawashima J, Motoshima H, Matsumura T, Kai H, Araki E
Mild Electrical Stimulation with Heat Shock Reduces Visceral Adiposity and Improves Metabolic Abnormalities in Subjects with Metabolic Syndrome or Type 2 Diabetes: Randomized Crossover Trials
EBioMedicine.2014 Nov;1(1):80-89.doi:10.1016/j.ebiom.2014.11.001

Suico MA, Fukuda R, Miyakita R, Koyama K, Taura M, Shuto T, Kai H.
The transcription factor MEF/Elf4 is dually modulated by p53-MDM2 axis and MEF-MDM2 autoregulatory mechanism.
J Biol Chem. 2014 Sep 19;289(38):26143-54. doi: 10.1074/jbc.M114.580209.

Matsuyama S, Moriuchi M, Suico MA, Yano S, Morino-Koga S, Shuto T, Yamanaka K, Kondo T, Araki E, Kai H.
Mild electrical stimulation increases stress resistance and suppresses fat accumulation via activation of LKB1-AMPK signaling pathway in C. elegans.
PLoS One.2014 Dec 9;9(12):e114690. doi: 10.1371/journal.pone.0114690.

Kondo T, Motoshima H, Igata M, Kawashima J, Matsumura T, Kai H, Araki E.
The role of heat shock response in insulin resistance and diabetes.
Diabetes Metab J. 2014 Apr;38(2):100-6. doi: 10.4093/dmj.2014.38.2.100. Review.

Aritomi K, Ishitsuka Y, Tomishima Y, Shimizu D, Abe N, Shuto T, Irikura M, Kai H, Irie T.
Evaluation of Three-Dimensional Cultured HepG2 Cells in a Nano Culture Plate System: an In Vitro Human Model of Acetaminophen Hepatotoxicity.
J Pharmacpl Sci. 2013; 124: 218-229.

Suzuki S, Shuto T, Sato T, Kaneko M, Takada T, Suico MA, Cyr DM, Suzuki H, Kai H
Inhibition of post-translational N-glycosylation by HRD1 that controls the fate of ABCG5/8 transporter.
Sci Rep. 2014 Mar 3;4:4258. doi: 10.1038/srep04258.

Sargent RG, Suzuki S, Gruenert DC.
Nuclease-Mediated Double-Strand Break (DSB) Enhancement of Small Fragment Homologous Recombination (SFHR) Gene Modification in Human-Induced Pluripotent Stem Cells (hiPSCs).
Methods Mol Biol. 2014;1114:279-90.

Ueno-Shuto K, Kato K, Tasaki Y, Sato M, Sato K, Uchida Y, Sakai H, Ono T, Suico MA, Mitsutake K, Tokutomi N, Kai H, Shuto T.
Lipopolysaccharide decreases single immunoglobulin interleukin-1 receptor-related molecule (SIGIRR) expression by suppressing Sp1 via TLR4-p38 pathway in monocytes and neutrophils.
J Biol Chem. Jun 27;289(26):18097-109. doi:10.1074/jbc.M113.532093jbc.M113.532093.