熊本大学大学院生命科学研究部 遺伝子機能応用学分野

Shuto T, Kamei S, Nohara H, Fujikawa H, Tasaki Y, Sugahara T, Ono T, Matsumoto C, Sakaguchi Y, Maruta K, Nakashima R, Kawakami T, Suico MA, Kondo Y, Ishigami A, Takeo T, Tanaka KI, Watanabe H, Nakagata N, Uchimura K, Kitamura K, Li JD, Kai H.
Pharmacological and genetic reappraisals of protease and oxidative stress pathways in a mouse model of obstructive lung diseases.
Sci Rep. 2016 Dec 16;6:39305.

Tasaki Y, Wang WY, Konduru AS, Komatsu K, Matsuyama S, Kai H, Li JD
cAMP-dependent protein kinase A acts as a negative regulator for nontypeable Haemophilus influenzae-induced GM-CSF expression via inhibition of MEK-ERK signaling pathway.
Integr Mol Med. 2016, DOI: 10.15761/IMM.1000261

Kondo T, Goto R, Ono K, Kitano S, Suico MA, Sato M, Igata M, Kawashima J, Motoshima H, Matsumura T, Kai H, Araki E.
Activation of heat shock response to treat obese subjects with type 2 diabetes: a prospective, frequency-escalating, randomized, open-label, triple-arm trial.
Sci Rep. 2016 Oct 19;6:35690.

Suico MA, Taura M, Kudo E, Gotoh K, Shuto T, Okada S, Kai H.
The ETS Factor Myeloid Elf-1-Like Factor (MEF)/Elf4 Is Transcriptionally and Functionally Activated by Hypoxia.
Biol Pharm Bull. 2016;39(4):641-7. doi: 10.1248/bpb.b15-00796.

甲斐 広文
医療機器と薬学
薬剤学2016;76(2):92-98

Suzuki S, Sargent RG, Illek B, Fischer H, Esmaeili-Shandiz A, Yezzi MJ, Lee A, Yang Y,Kim S, Renz P, Qi Z, Yu J, Muench MO, Beyer AI, Guimaraes AO, Ye L, Chang J, Fine EJ,Cradick TJ, Bao G, Rahdar M, Porteus MH, Shuto T, Kai H, Kan YW, Gruenert DC
TALENs Facilitate Single-step Seamless SDF Correction of F508del CFTR in Airway Epithelial Submucosal Gland Cell-derived CF-iPSCs.
Molecular Therapy Nucleic Acids (2016) 5, e273. doi:10.1038/mtna.2015.43

Fukuda R, Suico MA, Kai Y, Omachi K, Motomura K, Koga T, Komohara Y, Koyama K, Yokota T, Taura M, Shuto T, Kai H.
Podocyte p53 Limits the Severity of Experimental Alport Syndrome.
J Am Soc Nephrol. 2016 Jan;27(1):144-57. doi: 10.1681/ASN.2014111109.