Paper 2020
Genetic background, recent advances in molecular biology, and development of novel therapy in Alport syndrome
Nozu K, Takaoka Y, Kai H, Takasato M, Yabuuchi K, Yamamura T, Horinouchi T, Sakakibara N, Ninchoji T, Nagano C, Iijima K.
Kidney Res Clin Pract. 2020 Dec 31;39(4):402–413. doi:10.23876/j.krcp.20.111
Genetic background, recent advances in molecular biology, and development of novel therapy in Alport syndrome.
Nozu K, Takaoka Y, Kai H, Takasato M, Yabuuchi K,Yamamura T, Horinouchi T, Sakakibara N, Ninchoji T, Nagano C, Iijima K.
Kidney Res Clin Pract. 2020 Dec 31;39(4):402-413. doi: 10.23876/j.krcp.20.111.
Intrapopulation analysis of longitudinal lifespan in Caenorhabditis elegans identifies W09D10.4 as a novel AMPK-associated healthspan shortening factor
Nakano Y, Moriuchi M, Fukushima Y, Hayashi K, Suico MA, Kai H, Koutaki G, Shuto T.
J Pharmacol Sci. 2020 Dec doi:10.1016/j.jphs.2020.12.004
Mild electrical stimulation with heat shock attenuates renal pathology in adriamycin-induced nephrotic syndrome mouse model
Teramoto K, Tsurekawa Y, Suico MA, Kaseda S, Omachi K, Yokota T, Kamura M, Piruzyan M, Kondo T, Shuto T, Araki E, Kai H.
Scientific Reports. 2020 10:18719. doi:10.1038/s41598-020-75761-8
Combined effects of cisplatin and photon or proton irradiation in cultured cel ls: radiosensitization, patterns of cell death, and cell cycle distribution
Iwata H, Shuto T, Kamei S, Omachi K, Moriuchi M, Omachi C, Toshito T, Hashimoto S, Nakajima K, Sugie C, Ogino H, Kai H, Shibamoto Y.
Journal of Radiation Research. 2020 Sep 1-10.doi:10.1093/jrr/rraa065
A novel condition of mild electrical stimulation exerts immunosuppression via hydrogen peroxide production that controls multiple signaling pathway
Piruzyan M, Shitanda I, Shimauchi Y, Okita G, Tsurekawa Y, Moriuchi M, Nakano Y, Teramoto K, Suico MA, Shuto T, Kai H.
PLoS One.2020 June 22;15(6):e0234867.doi:10.1371/journal.pone.0234867
Development of an exon skipping therapy for X-linked Alport syndrome with truncating variants in COL4A5
Yamamura T, Horinouchi T, Adachi T, Terakawa M, Takaoka Y, Omachi K, Takasato M, Takaishi K, Shoji T, Onishi Y, Kanazawa Y, Koizumi M, Tomono Y, Sugano A, Shono A, Minamikawa S, Nagano C, Sakakibara N, Ishiko S, Aoto Y, Kamura M, Harita Y, Miura K, Kanda S, Morisada N, Rossanti R, Juan M Ye, Nozu Y, Matsuo M, Kai H, Iijima K, Nozu K.
Nature Commun. 2020 11:2777. doi:10.1038/s41467-020-16605-x
Higher Blood Uric Acid in Female Humans and Mice as a Protective Factor against Pathophysiological Decline of Lung Function
Fujikawa H, Sakamoto Y, Masuda N, Oniki K, Kamei S, Nohara H, Nakashima R, Maruta K, Kawakami T, Eto Y, Takahashi N, Takeo T, Nakagata N, Watanabe H, Otake K, Ogata Y, Tomioka H. N, Hosoyamada M, Takada T, Ueno-Shuto K, Suico M.A., Kai H, Saruwatari J, Shuto T.
MDPI.2020 May 9(5),387.doi:10.3390/antiox9050387
The DsbA-L gene is associated with respiratory function of the elderly via its adiponectin multimeric or antioxidant properties
Oniki K, Nohara H, Nakashima R, Obata Y, Muto N, Sakamoto Y, Ueno-Shuto K, Imafuku T, Ishima Y, Watanabe H, Maruyama T, Otake K, Ogata Y, Suico M.A., Kai H, Shuto T, Saruwatari J.
Scientific Reports. 2020 April 10:5973. doi:10.1038/s41598-020-62872-5
Intratracheal GLP-1 receptor agonist treatment up-regulates mucin via p38 and exacerbates emphysematous phenotype in mucus hypersecretory obstructive lung diseases
Nohara H, Nakashima R, Kamei S, Fujikawa H, Ueno-Shuto K, Kawakami T, Eto Y, Suico M.A., Li JD, Kai H, Shuto T.
Biochem Biophys Res Commun. 2020 April 524(2),332-339. doi.org/10.1016/j.bbrc.2020.01.081
Melinjo seed extract increases adiponectin multimerization in physiological and pathological conditions
Oniki K, Kawakami T, Nakashima A, Miyata K, Watanabe T, Fujikawa H, Nakashima R, Nasu A, Eto Y, Takahashi N, Nohara H, Suico M.A., Kotani S, Obata Y, Seguchi Y, Saruwatari J, Imafuku T, Watanabe H, Maruyama T, Kai H, Shuto T.
Scientific Reports. 2020 10:4313. doi:10.1038/s41598-020-61148-2
Trimerization and genotype-phenotype correlation of COL4A5 mutants in Alport syndrome
Kamura M, Yamamura T, Omachi K, Suico MA, Nozu K, Kaseda S, Kuwazuru J, Shuto T, Iijima K, Kai H.
Kidney International Reports. 2020 May;5(5):718-726.doi:10.1016/j.ekir.2020.01.008
Azithromycin inhibits constitutive airway epithelial sodium channel activation in vitro and modulates downstream pathogenesis in vivo
Fujikawa H, Kawakami T, Nakashima R, Nasu A, Kamei S, Nohara H, Eto Y, Ueno-Shuto K, Takeo T, Nakagata N, Suico MA, Kai H, Shuto T.
Biol Pharm Bull. 2020 Apr 1;43(4):725-730.doi:10.1248/bpb.b19-01091. Epub 2020 Jan 31.
