熊本大学大学院生命科学研究部 遺伝子機能応用学分野

Differential mode of cholesterol inclusion with 2-hydroxypropyl-cyclodextrins increases safety margin in treatment of Niemann-Pick disease type C.

Yamada Y, Ishitsuka Y, Kondo Y, Nakahara S, Nishiyama A, Takeo T, Nakagata N, Motoyama K, Higashi T, Arima H, Kamei S, Shuto T, Kai H, Hayashino Y, Sugita M, Kikuchi T, Hirata F, Miwa T, Takeda H, Orita Y, Seki T, Ohta T, Kurauchi Y, Katsuki H, Matsuo M, Higaki K, Ohno K, Matsumoto S, Era T, Irie T.
Br J Pharmacol. 2021 Jul;178(13):2727-2746. doi: 10.1111/bph.15464. Epub 2021 May 12.

Novel Keap1-Nrf2 Protein-protein interaction inhibitor UBE-1099 Ameliorates Progressive Phenotype in Alport Syndrome mouse model

Kaseda S, Sannomiya Y, Horizono J, Kuwazuru J, Suico M.A., Ogi S, Sasaki R, Sunamoto H, Fukiya H, Nishiyama H, Kamura M, Niinou S, Koyama Y, Nara F, Shuto T, Onuma K and Kai H.
Kidney360 December 2021, 10.34067/KID.0004572021; DOI: https://doi.org/10.34067/KID.0004572021

Activation of heat shock response improves biomarkers of NAFLD in patients with metabolic diseases.

Kondo T, Miyakawa N, Kitano S, Watanabe T, Goto R, Suico M.A., Sato M, Takaki Y, Sakaguchi M, Igata M, Kawashima J, Motoshima H, Matsumura T, Kai H, Araki E.
Endocrine Connections. 2021 May 10(5):521–533. doi:10.1530/EC-21-0084.

Metformin Ameliorates the Severity of Experimental Alport Syndrome

Omachi K, Kaseda S, Yokota T, Kamura M, Teramoto K, Kuwazuru J, Kojima H, Nohara H, Koyama K, Ohtsuki S, Misumi S, Takeo T, Nakagata N, Li JD, Shuto T, Suico M.A., Miner J.H., Kai H.
Scientific Reports.2021 11:7053 doi:10.1038/s41598-021-86109-1

The role of discoidin domain receptor 2 in the renal dysfunction of Alport syndrome mouse model

Sannomiya Y, Kaseda S, Kamura M, Yamamoto H, Yamada H, Inamoto M, Kuwazuru J, Niino S, Shuto T, Suico M.A., Kai H.
Renal Failure.2021 Mar;43:1,510-519.doi:10.1080/0886022X.2021.1896548

Type IV Collagen Variants in CKD: Performance of Computational Predictions for Identifying Pathogenic Variants

Shulman C, Liang E, Kamura M, Udwan K, Yao T, Cattran D, Reich H, Hladunewich M, Pei Y, Savige J, Paterson A D., Suico MA, Kai H, Barua M.
Kidney Medicine.2021 Feb. doi:10.1016/j.xkme.2020.12.007