熊本大学大学院生命科学研究部 遺伝子機能応用学分野

The 2019 and 2021 International Workshops on Alport Syndrome.

Daga S, Ding J, Deltas C, Savige J, Lipska-Ziętkiewicz BS, Hoefele J, Flinter F, Gale DP, Aksenova M, Hirofumi K, Perin L, Barua M, Torra R, Miner JH, Massella L, Ljubanović DG, Lennon R, Weinstock AB, Knebelmann B, Cerkauskaite A, Gear S, Gross O, Turner AN, Baldassarri M, Pinto AM, Renieri A.

Eur J Hum Genet. 2022 May;30(5):507-516. doi: 10.1038/s41431-022-01075-0. Epub 2022 Mar 9.

Seamless Gene Correction in the Human Cystic Fibrosis Transmembrane Conductance Regulator Locus by Vector Replacement and Vector Insertion Events

Suzuki S,Chosa K,Barillà C,Yao M, Zuffardi O,Kai H,Shuto T,Suico M.A.,Kan YW,Sargent RG,Gruenert DC.
Front Genome Ed. 2022 Apr 6;4:843885. doi: 10.3389/fgeed.2022.843885. eCollection 2022.

Negative Cross-Talk between TLR2/4-Independent AMPKα1 and TLR2/4-Dependent JNK Regulates S. pneumoniae–Induced Mucosal Innate Immune Response

Matsuyama S, Komatsu K, Lee BC, Tasaki Y, Miyata M, Xu H, Shuto T, Kai H, Li JD.
J Immunol. 2022 Oct 15;209(8):1532-1544. doi: 10.4049/jimmunol.2100901. Epub 2022 Sep 2.

A Splice Switch in SIGIRR Causes a Defect of IL-37-Dependent Anti-Inflammatory Activity in Cystic Fibrosis Airway Epithelial Cells.

Shuto-Ueno K, Kamei S, Hayashi M, Fukuyama A, Uchida Y, Tokutomi N, Suico M.A., Kai H, Shuto T.
Int. J. Mol. Sci. 2022, 23(14), 7748; https://doi.org/10.3390/ijms23147748

Metformin suppresses epithelial sodium channel hyperactivation and its associated phenotypes in a mouse model of obstructive lung diseases

Nakashima R, Nohara H, Takahashi N, Nasu A, Hayashi M, Kishimoto T, Kamei S, Fujikawa H, Maruta K, Kawakami T, Eto Y, Ueno-Shuto K, Suico M.A., Kai H, Shuto T.
Journal of Pharmacological Sciences. 2022. 149(2),37-45. doi:10.1016/j.jphs.2022.03.002

NanoLuc reporters identify COL4A5 nonsense mutations susceptible to drug-induced stop codon readthrough

Omachi K, Kai H, Roberge M, Miner J.H.
iScience. 2022 Mar 18; 25(3):103891 doi: 10.1016/j.isci.2022.103891

Nitric oxide facilitates the targeting Kupffer cells of a nano-antioxidant for the treatment of NASH

Maeda H, Ishima Y, Saruwatari J, Mizuta Y, Minayoshi Y, Ichimizu S, Yanagisawa H, Nagasaki T, Yasuda K, Oshiro S, Taura M, McConnell MJ, Oniki K, Sonoda K, Wakayama T, Kinoshita M, Shuto T, Kai H, Tanaka M, Sasaki Y, Iwakiri Y, Otagiri M, Watanabe H, Maruyama T.
J Control Release. 2022 Jan;341:457-474. doi: 10.1016/j.jconrel.2021.11.039. Epub 2021 Nov 29.