熊本大学大学院生命科学研究部 遺伝子機能応用学分野

A Splice Switch in SIGIRR Causes a Defect of IL-37-Dependent Anti-Inflammatory Activity in Cystic Fibrosis Airway Epithelial Cells.

Keiko Shuto,Shunsuke K,Megumi H,Ayami F,Yuji U,Naofumi T,Suico M.A.,Hirofumi K, Tsuyoshi S.
Int. J. Mol. Sci. 2022, 23(14), 7748; https://doi.org/10.3390/ijms23147748

Metformin suppresses epithelial sodium channel hyperactivation and its associated phenotypes in a mouse model of obstructive lung diseases

Nakashima R, Nohara H, Takahashi N, Nasu A, Hayashi M, Kishimoto T, Kamei S, Fujikawa H, Maruta K, Kawakami T, Eto Y, Ueno-Shuto K, Suico M.A., Kai H, Shuto T.
Journal of Pharmacological Sciences. 2022. 149(2),37-45. doi:10.1016/j.jphs.2022.03.002

NanoLuc reporters identify COL4A5 nonsense mutations susceptible to drug-induced stop codon readthrough

Omachi K, Kai H, Roberge M, Miner J.H.
iScience. 2022 Mar 18; 25(3):103891 doi: 10.1016/j.isci.2022.103891

Nitric oxide facilitates the targeting Kupffer cells of a nano-antioxidant for the treatment of NASH

Maeda H, Ishima Y, Saruwatari J, Mizuta Y, Minayoshi Y, Ichimizu S, Yanagisawa H, Nagasaki T, Yasuda K, Oshiro S, Taura M, McConnell MJ, Oniki K, Sonoda K, Wakayama T, Kinoshita M, Shuto T, Kai H, Tanaka M, Sasaki Y, Iwakiri Y, Otagiri M, Watanabe H, Maruyama T.
J Control Release. 2022 Jan;341:457-474. doi: 10.1016/j.jconrel.2021.11.039. Epub 2021 Nov 29.