熊本大学大学院生命科学研究部 遺伝子機能応用学分野

Yasuaki Hashimoto, Tsukasa Okiyoneda, Kazutsune Harada, Keiko Ueno,Takuya Sugahara, Atsushi Yamashita, Tsuyoshi Shuto, Mary Ann Suico,and Hirofumi Kai Phosphatidic acid metabolism regulate the intracellular trafficking and retrotranslocation of cystic fibrosis transmembrane conductance regulator.BBA-Mol Cell Res. 2008, 1783(1), 153-162

Susuki S., Ando Y., Sato T., Nishiyama M., Miyata M., Suico MA., Shuto T., Kai H., Multi-elemental analysis of serum and amyloid fibrils in familial amyloid polyneuropathy patients. Amyloid (The Journal of Protein Folding Disorders) 15(2):108-116, 2008

Koga T., Lim J.H., Jono H., Ha U.H., Xu H., Ishinaga H., Morino S., Xu X., Yan C., Kai H., Li J.D., Tumor suppressor cylindromatosis (CYLD) acts as a negative regulator for Streptococcus pneumoniae-induced NFAT signaling. J. Biol. Chem. 283(18):12546-54,2008

Oba M., Yano S., Shuto T., Suico M.A., Eguma A., and Kai H. Interferon-gamma down-regulated Hsp27 and enhances hyperthermia-induced tumor cell death in vitro and tumor suppression in vivo. Int. J. Oncol. 32:1317-1324, 2008

Suwa Y., Nakamura T., Toma S., Ikemizu S., Kai H., Yamagata Y., Preparation, crystallization and preliminary X-ray diffraction analysis of the DNA-binding domain of the Ets transcription factor in complex with target DNA. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 64(Pt 3):171-4, 2008.

Hidaka M., Nagata M., Kawano Y., Sekiya H., Kai H., Yamasaki K., Okumura M., Arimori K., Inhibitory effects of fruit juices on cytochrome P450 2C9 activity in vitro. Biosci. Biotechnol. Biochem. 72(2):406-11, 2008.

Ueno K., Koga T., Kato K., Golenbock D.T., Gendler S.J., Kai H., and KimK.C., MUC1 mucin is a negative regulator of toll-like receptor signaling.Am. J. Respir. Cell Mol. Biol. 38(3):263-268, 2008.

Iwakiri T., Okumura M., Matsunaga N., Ichihara E., Shiotsuki S., Nagata M.,Kumagai Y., Kai H., and Arimori K., Hepatocyte growth factor increasesuptake of estradiol 17beta-d-glucuronide and Oatp1 protein level in rathepatocytes. Eur. J. Pharmacol. 580: 19-26, 2008.

Okiyoneda T.,. Niibori A., Harada K.,. Kohno T., Michalak M., Duszyk M., Wada I., Ikawa M.,. Shuto T., Suico M.A,, Kai H. Role of calnexin in the ER quality control and productive folding of CFTR; differential effect of calnexin knockout on wild-type and DF508 CFTR.  BBA - Molecular Cell Research,1783:1585-94, 2008

Takashi Furuta, Tsuyoshi Shuto, Shogo Shimasaki, Yuko Ohira, Mary AnnSuico, Dieter C Gruenert and Hirofumi Kai. DNA demethylation-dependent enhancement of toll-like receptor-2 gene expression in cystic fibrosis epithelial cells involves SP1-activated transcription. BMC Molecular Biology. Apr 21;9:39, 2008

Seo T, Ishitsu T, Oniki K, Abe T, Shuto T, Nakagawa K, ABCC2 haplotype is not associated with drug-resistant epilepsy but with mental retardation. J Pharm Pharmacol 60, 631-635, 2008

Manabu Taura, Ayaka Eguma, Mary Ann Suico, Tsuyoshi Shuto, Tomoaki
Koga,Kensei Komatsu, Takefumi Komune, Takashi Sato, Hideyuki Saya, Jian-Dong
Li and Hirofumi Kai, p53 regulates TLR3 expression and function in human
epithelial cell lines. Mol. Cell. Biol. 28(21):6557-67, 2008

Jaemi Kim, Yoshihiro Motomiya, Mitsuharu Ueda, Masaaki Nakamura, Yohei
Misumi, Shiori Saito, Shinji Ikemizu, Shogo Misumi, Kazutoshi Ota, Satoru
Shinriki, Hirofumi Kai and Yukio Ando, Role of conformational change in the
C-terminus of β2-microglobulin in dialysis-related amyloidosis. Ann. Clin.
Biochem. 45:489-495,2008.

Saori Morino, Mary Ann Suico, Tatsuya Kondo, Erika Sekimoto, Shuichiro Yano. Tomoko Matsuda, Takashi Matsuno, Tsuyoshi Shuto, Eiichi Araki, and Hirohumi Kai. Mild Electrical Stimulation Increases Ubiquitinated Proteins and Hsp72 in A549 Cells via Attenuation of Proteasomal Degredation. J Pharmacol Sci. 108,222-226 (2008)

Kensei Komatsu, Hirofumi Jono, Jae Hyang Lim, Akira Imasato, Haidong Xu, Hirofumi Kai, Chen Yan and Jian-Dong Li, Glucocorticoids inhibit nontypeable Haemophilus influenzae-induced MUC5AC mucin expression via MAPK phosphatase-1-dependent inhibition of p38 MAPK. Biochem. Biophys. Res. Commun.377(3):763-8(2008)

Toru Murakami, Hideaki Harada, Mary Ann Suico, Tsuyoshi Shuto, Shinya Suzu, Hirofumi Kai, and Seiji Okada, Ephedrae Herba, a Component of Japanese Herbal Medicine Mao-to, Efficiently Activates the Replication of Latent Human Immunodeficiency Virus Type 1 (HIV-1) in a Monocytic Cell Line. Biol. Pharm. Bull. 31(12)2334-2337(2008)

Saori Morino, Tatsuya Kondo, Kazunari Sasaki, Hironori Adachi, Mary Ann Suico, Erika Sekimoto, Tomoko Matsuda, Tsuyoshi Shuto, Eiichi Araki, and Hirofumi Kai. Mild Electrical Stimulation with heat shock ameliorates insulin resistance via enhanced insulin signaling. Increases Ubiquitinated Proteins and Hsp72 in A549 Cells via Attenuation of Proteasomal Degredation. PLoS ONE 3(12):e4068 (2008)

Takashi Sato, Seiko Susuki, Masanori Miyata, Yukio Ando, Tsuyoshi Shuto, Mary Ann Suico and Hirofumi Kai, Inhibition of intracellular tetramerization induces the proteasomal degradation of amyloidogenic transthyretin variants.XIth International Symposium on Amyloidosis (Edited by M.Skinner, J.L. Berk, L.H. Connors, D.C. Seldin) CRC Press pp188-190 (2008)

甲斐広文、森野沙緒里、近藤龍也、荒木栄一、微弱パルス電流の新たな生物活性とその治療的応用、「化学工業」Vol.59 No.12, 57-61(2008)

村上 徹、首藤 剛、甲斐広文、岡田誠治、竹内 晃 NK細胞に対する温熱の影響 「がんの温熱免疫療法―ハイパーサーミック●イムノロジーー」吉川敏一監修、診断と治療社(株)pp38-42 (2008)