The American Society for Cell Biology 48th Annual Meeting (2008.12.13-7) San Francisco, USA

"p53 Regulates TLR3 Expression and Function in Human Epthelial Cell Lines"
A. Eguma , M. Taura , M. Suico , T. Shuto , T. Koga , K. Komatsu , T.Komune , T. Sato ,H. Saya , J. Li, H. Kai

" Curcumin Inhibits Peptidoglycan-Mediated Inflammatory Response in Human Cystic Fibrosis Bronchial Epithelial Cells through Inhibition of TLR2 Gene"
Y. Ohira, T.Shuto,S. Shimasaki,K. Watanabe, M. Suico,H. Kai.

The 22nd Annual North American Cystic Fibrosis Conference(2008.10.23-25) Orland, Florida, USA

"ER RETENTION OF CFTR IS CRUCIAL FOR SP1-DEPENDENT UP-REGULATION OF TLR2 EXPRESSION IN ΔF508-CFTR-EXPRESSING CF BRONCHIAL EPITHELIAL CELLS"
Shimasaki,S.; Shuto,T.; Watanabe,K.; Ohira,Y.; Furuta,T.; Suico,M.S.; Gruenert,D.C.; Kai,H.

"INCREASED SCRATCHING BEHAVIOR AND SUSCEPTIBILITY TO DERMATITIS IN MITE-INEFCTED ΔF508 CFTR MICE"
Mizunoe.S , Hashimoto.Y , Shuto.T , Tomita.A , Takano.N , Takeya.M , Scholte.B.J , Suico.M.S , Niibori.A , Sugahara.T , Kai.T

VIIth International Symposium on Familial Amyloid Polyneuropathy and Ist International Workshop on Hereditary Amyloidosis(2008.9.2-5)London,UK

"The endoplasmic reticulm retention and degradation of transthyretin are regulated by the molecular chaperone BiP in mammalian cells"
Seiko Susuki, Takashi Sato, Masanori Miyata, Mary Ann Suico, Tsuyoshi Shuto, Yukio Ando and Hirofumi Kai

"The role of coat protein complex II machinery on the secretion, endoplasmic reticulum retention and endoplasmic reticulum-associated degradation of transthyretin"
Takashi Sato,Seiko Susuki, Masanori Miyata, Mary Ann Suico, Tsuyoshi Shuto, Yukio Ando, Hirofumi Kai

"Glu54 mutations in transthyretin affect thyroxine binding and tetramer stability, resulting in aggressive familial amyloid polyneuropathy"
Masanori Miyata, Takashi Sato,Seiko Susuki, Mineyuki Mizuguchi, Yukio Ando, Mary Ann Suico, Tsuyoshi Shuto, Yuriko Yamagata and Hirofumi Kai

Joint International Symposium on Cell Fate Regulation: Development,
Degeneration and Regeneration in the Central Nervous System (2008. July 15-17) Rochester, NY, USA

"Intracellular protein traffic in familial amyloidosis polyneuropathy"
Hirofumi Kai

"p53 regulates TLR3 expression in human epithelial cell lines"
Mary Ann Suico

"Genetic and epigenetic regulation of TLR2 during inflammation"
Tsuyoshi Shuto

"NFAT signaling is negatively regulated by CYLD via a deubiquitination-dependent mechanism"
Tomoaki Koga

"Glucocorticoids inhibit Nontypeable Haemophilus influenzae induced MUC5AC mucin expression via MAPK Phosphatase-1-dependent inhibition of p38 MAPK"
Kensei Komatsu

Gordon Research Conferences BIOLOGY OF ACUTE RESRIRATORY INFECTION (2008.3.9-14) Ventura,California

" Tumor Suppressor Cylindromatosis acts as a negative regulator for nontypeable Haemophilus influenzae-induced Toll-like receptor 7 expression in epithelial cells. "
Tomoaki Koga

" Elucidation of negative regulatory mechanism of Pseudomonas aeruginosa flagellin-induced TLR5 signaling by membrane-tethered mucin,MUCI."
Kosuke Kato

" Muc1 mucin is a negative regulator of Toll like receptor signaling."
Keiko Ueno

The 1st Kumamoto University Global COE International Symposium on Cell Fate Regulation (1. 16, 2008, Kumamoto)

Endoplasmic reticulum quality control regulates the fate of transthyletin variants in the cell.
Sato.K , Seiko Susuki, Mary Ann Suico, Masanori Miyata, Yukio Ando, Mineyuki Mizuguchi, Makoto Takeuchi, Mizuki Dobashi , Tsuyoshi Shuto and Hirofumi Kai

Hsp72 up-regulation improves glucose homeostasis and insulin resistance in type 2 diabetes mouse models.
Morino. S , Tatsuya Kondo , Kazunari Sasaki , Hironori Adachi , Erika Sekimoto , Shuichiro Yano , Tomoko Matsuda , Mary Ann Suico , Tsuyoshi Shuto , Eiichi Araki ,  Hirofumi Kai

The role of BiP on secretion and ERAD of transthyretin variants.
Susuki.S , Takashi Sato, Mary Ann Suico, Masanori Miyata, Tsuyoshi Shuto, Hirofumi Kai

IFN-g suppresses Hsp27 expression and enhances cell death induced by hyperthermia.
Oba.M , Yano.S , Shuto.T , Suico.MA , Kai.H.

DNA demethylation-dependent enhancement of toll-like receptor-2 gene expression in cystic fibrosis epithelial cells involves SP1-activated transcription.
Shimasaki , S.

Functional analysis of calreticulin on epithelial sodium channel (ENaC) biosynthesis.
Sugahara.T , Ueno.K , Shuto.T , Watanabe.E , Mizunoe.S , Kitamura.K , Maekawa.A , Tomita.K , Suico.M.A , and Kai, H.

Glu54 mutations of transthyretin decrease thyroxine binding and tetramer stability, resulting in aggressive familial amyloid polyneuropathy.
Miyata.M , Takashi Sato, Mizuguchi Mineyuki, Teruya Nakamura, Shinji Ikemizu, Makoto Takeuchi, Seiko Susuki, Yukio Ando, Mary Ann Suico, Tsuyoshi Shuto, Yuriko Yamagata and Hirofumi Kai

Tumor Suppressor CYLD Acts as a Negative Regulator for Bacteria-induced NFAT Signaling.
Koga.T , Jae Hyang Lim , Hirofumi Jono , Un Hwan Ha , Haidong Xu , Hajime Ishinaga , Saori Morino , Chen Yan , Hirofumi Kai , and Jian-Dong Li