熊本大学大学院生命科学研究部 遺伝子機能応用学分野

International conference 2015

2015 cell biology ascb annual meeting(2015.12.12-16)
San Diego Convention Center, San Diego, CA

"Molecular mechanism of the intracellular quality control of TTR by Hsp47 "
Y. Wakita, R. Yamakawa, K. Chosa, S. Takaki, Y. Teranishi, T. Sato, M.Suico, T. Shuto, H. Kai

"A novel physiological and pathophysiological role of glucagon-like peptid-1 signal in the regulation of airway mucin secretion "
H. Nohara, T. Shuto, S. Kamei, R. Nakashima, S. Kamei, H. Fujikawa, K. Maruta, M. Suico, D.C. Gruenert, H. Kai

"A novel splicing variant of zinc transporter ZIP2 controls the pathology of CF and CF-like airway diseases. "
S. Kamei, T. Shuto, K. Shuto, H. Fujikawa, K. Maruta, H. Nohara, R. Nakashima, M. Suico, D.C. Gruenert, H. Kai

"Glomerular proteome analysis revealed progressive mitochondrial dysfunction in Alport syndrome mouse model "
M. Kamura, K. Omachi, T. Yokota, K. Motomura, K. Teramoto, M. Suico, T. Shuto, H. Kai

International Symposium on Chronic Inflammatory Diseases, Kumamoto (ISCIDK2015)(2015.10.16-17)
Kumamoto Unv., Kumamoto, Japan

"Beneficial effects and the molecular mechanisms of specific mild electrical stress as physical medicine "
H. Kai, T. Kondo, M.A. Suico, T. Shuto E. Araki

"Podocyte p53 limits the severity of experimental Alport syndrome "
M.A. Suico, R. Fukuda, Y. Kai, K. Omachi, K. Motomura, T. Koga, K. Koyama, T. Yokota, M. Taura, T. Shuto, H. Kai

"Pharmacological and genetic approaches determine protease and oxidative stress as exacerbating factors in a mouse model of obstructive lung diseases "
T. Shuto, S. Kamei, H. Nohara, H. Fujikawa, Y. Sakaguchi, C. Matsumoto, T. Ono, T. Sugahara, M.A. Suico, K. Mitsutake, H. Kai

"Clarify the intracellular stress response in early-stage Alport Syndrome (AS) and establish an evaluation system for intracellular regulation of COL4A5, the causal protein for AS "
K. Omachi, M. Kamura, K. Teramoto, T. Yokota, K. Motomura, R. Fukuda, M. Suico, T. Shuto, H. Kai

"Establishment of fluorescence resonance energy transfer (FRET) system that monitors the trimerization of COL4A proteins, the causal proteins for Alport syndrome "
K. Teramoto, K. Omachi, M. Kamura, M. Suico, T. Shuto, H. Kai

"Glomerular proteome analysis reveals progressive mitochondrial dysfunction in Alport syndrome mouse model "
M. Kamura, K. Omachi, K. Teramoto, T. Yokota, K. Motomura, S. Kotani, M. Suico, T. Shuto, S. Misumi, H. Kai

"p53 exacerbates LPS-induced acute kidney injury possibly through TLR4 up-regulation in podocyte "
K. Motomura, R. Fukuda, T Yokota, M. Suico, T. Shuto, H. Kai

"FAM105A suppresses lipopolysaccharide-induced inflammatory response in human monocytes THP-1 "
T. Yokota, R. Fukuda, M. Suico, T. Shuto, T. Koga, K. Koyama, H. Kai

"IncuCyte-based non-invasive method of analyzing the life span of C. elegans "
M. Moriuchi, T. Shuto, Y. Nakano, M. Suico, K. Nanri, T. Ueno, H. Kai

"The immunosuppressive effect of mild electrical stimulation via NFAT pathway is a promising therapeutic approach for inflammation "
M. Piruzyan, I. Shitanda, Y. Shimauchi, M. Suico, T. Shuto, H. Kai

"Mild electrical stimulation suppresses IL22 mRNA expression in imiquimod-induced psoriasis mouse model "
Y. Tsurekawa, M. Suico, M. Moriuchi, G. Okita, Y. Nakano, M. Piruzyan, M. Takada, M. Morita, T. Shuto, H. Kai

"Mild Pulse Electrical Stimulation regulates Alzheimer's disease pathology"
G. Okita, M. Takada, K. Mitsutake, T. Shuto, M. Suico, H. Kai

"High-fat diet exaggerates pulmonary dysfunction and emphysema in a mouse model of obstructive lung diseases:Possible contribution of local insulin resistance in lung tissue "
H. Nohara, T. Shuto, S. Kamei, H. Fujikawa, R. Nakashima, K. Maruta, M. Suico, D.C. Gruenert, H. Kai

"Physiological and pathophysiological induction of pulmonary mucus hypersecretionby GLP-1 receptor agonist Exendin-4"
H. Nohara, R. Nakashima, T. Shuto, S. Kamei, H. Fujikawa, K. Maruta, C. Matsumoto, Y. Sakaguchi, M. Suico, D.C. Gruenert, H. Kai

"The effect of Uricase inhibitor on respiratory function and emphysema in murine models of obstructive pulmonary disease"
H. Fujikawa, T. Shuto, S. Kamei, H. Nohara, K. Maruta, R. Nakashima, M. Suico, T. Takeo, N. Nakagata, H. Kai

"A novel splicing variant of zinc transporter ZIP2 controls the pathology of CF and CF-like airway diseases"
S. Kamei, T. Shuto, K. Ueno-Shuto, H. Fujikawa, K. Maruta, H. Nohara, R. Nakashima, C. Matsumoto, Y. Sakaguchi, M. Suico, D.C. Gruenert, H. Kai

"CFTR-dependent dysregulation of specific lncRNAs with unknown function in cystic fibrosis airway epithelial cells"
S. Kamei, K. Maruta, T. Shuto, H. Fujikawa, H. Nohara, R. Nakashima, Y. Tasaki, K. Ueno-Shuto, M. Suico, D.C. Gruenert, H. Kai

"6-benzoyl-2-hydroxy-1H-benzo[de]isoquin oline-1,3(2H)-dione is a novel transthyretin stabilizer for familial amyloid polyneuropathy"
S. Takaki, K. Chosa, T. Yokoyama, Y. Teranishi, Y. Wakita, T. Sato, M. Suico, T. Shuto, M. Mizuguchi, H. Kai

"High throughput screening-based identification of transthyretin stabilizers for familial amyloid polyneuropathy"
Y. Teranishi, K. Chosa, T. Shuto, S. Takaki, Y. Wakita, T. Sato, M. Suico, T. Yamashita, H. Kai

"The molecular quality control of TTR by Hsp47 "
Y. Wakita, R. Yamakawa, K. Chosa, S. Takaki, Y. Teranishi, T. Sato, S. Ann, T. Shuto, H. Kai

The 74th Annual Meeting of the Japanese Cancer Association(2015.10.8-10)
Nagoya Congress Center, Nagoya, Japan

"Myeloid Elf-1-like Factor (MEF)/Elf-4 is Induced by HIF1/Hypoxia and contributes to VEGF regulation "
Mary Ann Suico, Manabu Taura, Eriko Kudo, Tsuyoshi Shuto, Seiji Okada, Hirofumi Kai

The 2015 International workshop on Alport Syndrome(2015.9.25-27), Germany

Award for the best poster presentation
Cellular-based assay clarifies the regulation of Alport syndrome-related protein COL4A5
K. Omachi

Award for the best young investigator presentation
Glomerular Proteome Analysis Revealed Progressive Mitochondrial Dysfunction in Alport Syndrome Mouse Model
M. Kamura

52nd ERA-EDTA CONGRESS LONDON 2015(2015.5.28-31)
ExCeL London, London, UK

"Characterization of the intracellular behavior of COL4A5 and clarification of molecular mechanism of alport syndrome"
K. Omachi, M. Kamura, K. Teramoto, R. Fukuda, M. Suico, T. Shuto, H. Kai

「修飾シグナル病」第2回国際シンポジウム(2015.1.23-24)
東京大学医科学研究所, 東京

"Podocyte-p53 is essential to control the progression of hereditary renal disease Alport syndrome"
H. Kai